嗜铬粒蛋白A(CGA)属于酸性可溶性蛋白质家族,是一种由肾上腺髓质合成,与儿茶酚胺共分泌的应激标志物。研究发现,CGA及其衍生多肽在内环境稳态的保持、钙和葡萄糖的新陈代谢、心血管功能、炎性反应、疼痛缓解、组织修复和胃肠运动中都有重要作用。近年来研究表明,CGA及其衍生多肽还具有抗菌和免疫调节的作用,并且它在这方面的作用得到越来越多的重视。该文CGA及其衍生多肽在天然免疫系统中作用的研究进展予以综述。 Chromogranin A (CGA), a family of acidic soluble proteins, is a stress marker synthesized by the adrenal medulla and co-secreted with catecholamines. It has been found that CGA and its derivatized peptides play an important role in homeostasis, metabolism of calcium and glucose, cardiovascular function, inflammatory response, pain relief, tissue repair and gastrointestinal motility. In recent years, studies have shown that CGA and its derivatives also have antibacterial and immunomodulatory effects, and its role in this regard have received more and more attention. This article reviews the role of CGA and its derivatives in the innate immune system.