Grebe型软骨发育不全以四肢短畸、智力正常为特点的先天性疾病。德国Grebe(1952)首先报告此病,因此,又叫Grebe综合征。1968年巴西Que-Lce-Saly-ado报告47例病人,90％是近亲结婚,因此,又叫巴西型软骨发育不良。至1978年,在世界文献中大约有54例报告。1983年,作者在本县农村再次发现两例。 Grebe-type achondroplasia is a congenital disorder characterized by short-limbed abnormalities and normal intelligence. Grebe, Germany (1952) first reported the disease, therefore, also known as Grebe syndrome. In 1968, Que-Lce-Saly-ado, Brazil reported 47 cases of patients and 90% of them were relatives married. Therefore, it is also called Brazilian type of cartilage dysplasia. By 1978, there were about 54 reports in the world literature. In 1983, the author found two more cases in the rural area of ​​this county.