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病毒性肝炎是常见病,估计全世界有1.5—2亿人有乙型肝炎病毒(HBV)感染。我国是乙型肝炎高发区,各地流行极为严重。急性肝炎在适当治疗下多可痊愈,但一旦转为慢性肝炎则顽固难治。因此,积极研究防治慢性肝炎的有效方法,是我们医务工作者刻不容缓的重要任务。慢性肝炎的发病机理迄今尚未阐明。但多数认为HBV在人体内的持续感染是导致乙型肝炎转变为慢性的基本原因。有人提出在慢性肝炎病人血清中,约有25～50％为乙型肝炎表面抗原(HBsAg)阳性。根据英国的研究,HBsAg阴性的慢性活动性肝炎(CAH)病人中,有63％的病人具有对HBsAg的细胞免疫反应(白细胞移动抑制),表示大多数HBsAg阴性的CAH病人以往感染过HBV。因此,有人主张,无论有无HBsAg血症,大多数慢性肝炎病人都是HBV感染的慢性结果。HBV虽
Viral hepatitis is a common disease and it is estimated that 1.5-2 billion people worldwide have Hepatitis B virus (HBV) infection. Our country is a high incidence area of hepatitis B, and the epidemic is extremely serious all over the country. Acute hepatitis can be cured under the appropriate treatment, but once converted to chronic hepatitis is stubborn refractory. Therefore, active research on effective prevention and treatment of chronic hepatitis is an urgent task for our medical workers. The pathogenesis of chronic hepatitis has not yet been elucidated. However, most believe that persistent HBV infection in humans is the basic cause of chronic hepatitis B conversion. It has been suggested that about 25% to 50% of sera from patients with chronic hepatitis are positive for hepatitis B surface antigen (HBsAg). According to the British study, 63% of patients with HBsAg-negative chronic active hepatitis (CAH) have a cellular immune response to HBsAg (leukocyte migration inhibition), indicating that most patients with HBsAg-negative CAH have previously had HBV infection. Therefore, it is argued that most patients with chronic hepatitis, regardless of HBsAg, are the chronic cause of HBV infection. Although HBV