论文部分内容阅读
【目的】探讨 X线修复交错互补基因1（XRCC1） Codon399单核苷酸多态性与非小细胞肺癌（NSCLC）患者放射性损伤的相关性。【方法】收集经皮肺穿刺活检病理确诊为 NSCLC患者60例，采用xTAG液相芯片技术检测XRCC1 Codon399的3种基因型：Arg／Arg纯合子、Arg／Gln杂合子、Gln／Gln纯合子。随访至放疗结束后3个月，评价急性放射性损伤与不同基因型的关系。【结果】Arg／Gln杂合子组患者发生急性放射性肺损伤的比例高于两组纯合子（ P ＜0．05），Arg／Gln和Gln／Gln组患者在上消化道损伤方面要高于Arg／Arg纯合子组（ P＜0．05）。三种基因型在皮肤、咽和食管损伤以及白细胞、血小板、血红蛋白等血液细胞学指标上比较无显著差异（ P ＞0．05）。【结论】XRCC1 Codon399单核苷酸多态性与晚期 NSCLC患者肺部及上消化道的急性放射性损伤有关，其有望成为放射治疗副作用的预测因子之一。“,”Objective] To explore the correlation between single nucleotide polymorphism of X‐ray repair cross complementary gene 1 (XRCC1) codon399 and radiation‐induced injury in patients with non‐small cell lung cancer(NSCLC) .[Methods] A total of 60 patients with NSCLC pathologically confirmed by percutaneous lung puncture biopsy were collected .The xTAG liquid chip was used to detect the 3 genotypes of XRCC1 co‐don399 including Arg/Arg heterozygote ,Arg/Gln heterozygote and Gln/Gln homozygote .All patients were followed up until 3 months after radiotherapy .The correlation between acute radiation‐induced injury and dif‐ferent genotypes was evaluated .[Results] The patients with Arg/Gln heterozygote had a higher rate of acute radiation‐induced pulmonary injury than the patients with homozygote( P<0 .05) ,and the patients with Arg/Gln heterozygote and Gln/Gln homozygote had a higher rate of upper digestive tract injury than the patients with Arg/Arg homozygote( P 0 .05) .[Conclusion] Single nucleotide polymorphism of XRCC1 codon399 is related with acute irradiation‐induced injury of lung and upper gastrointestinal tract in patients with advanced NSCLC .It is ex‐pected to be one of the predictive factors with the side effect of radiotherapy .