本研究利用3700多例、为期1年的4个双盲大型研究结果,首次比较了噻唑烷二酮类(PI)、二甲双胍类(M)和磺酰脲类(G)口服降糖药在2型糖尿病治疗中的安全性和耐受性。结果表明这些治疗全部安全且没有不期望的器官毒性。对PI有一个重要的发现,其45mg的剂量(比早期研究所定的高),无论 In this study, we used the large double-blind study of more than 3700 cases for one year to compare the efficacy and safety of oral hypoglycemic agents of thiazolidinediones (PI), metformin (M) and sulfonylureas (G) Safety and tolerability in the treatment of type 2 diabetes. The results show that these treatments are all safe and have no unwanted organ toxicity. An important finding for PI is that at a 45 mg dose (higher than that set forth in earlier studies), either