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HBsAg阴性母亲的新生儿,按0、1、6个月程序接种3剂10μg乙型肝炎血源疫苗,在第一针免疫后9～48个月观察抗-HBs阳转率,发现免后12个月阳转率最高达94.23％;至48个月为81.62％。48个月后抗-HBs GMT仍有263.5mIU/ml,提示此期间不必加强免疫。抗-HBs滴度(mIU/ml)的动态规律是由高滴度(>1000mIU/ml)向低滴度推移。
HBsAg-negative mothers of newborns, 0,1,6 months according to the program of three doses of 10μg Hepatitis B blood vaccine in the first needle 9 to 48 months after the observation of anti-HBs positive rate found after 12 Month positive conversion rate up to 94.23%; to 48 months was 81.62%. After 48 months there was still 263.5 mIU / ml of anti-HBs GMT, suggesting that there was no need to boost the immunization during this period. The dynamic pattern of anti-HBs titer (mIU / ml) is shifted from high titers (> 1000 mIU / ml) to low titers.