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作者汇集了有关用甲基强的松龙冲击疗法治疗多发性硬化的报告。发现在147次治疗的病例中有效110例(74.8%)。治疗对象几乎都是急性恶化者。Trotter 等报告的12例中9例无效,几乎都是急性恶化期以外的病人。大多给予甲基强的松龙1000mg,静脉点滴3～4小时,连用3天或5～7天。然后给予强的松或强的松龙口服或静注,逐渐减量停用。Dowling 等发现7例中有5例在开始治疗后96小时内获确实的临床效果。其中1例两眼视力障碍、眼震、左下肢运动障碍和病理反射的15岁男孩,对口服强的松60mg 的治疗无效。而冲击疗法开始后20小时左眼视力开始改善,39小时时左眼视力正常,右眼视力也开始改
The authors compiled a report on treatment of multiple sclerosis with methylprednisolone impact therapy. 110 cases (74.8%) were found to be effective in 147 treated cases. Almost all of the treatment of acute exacerbation. Nine of the 12 patients reported by Trotter et al were ineffective, almost all of whom were outside of the acute exacerbation. Most give methylprednisolone 1000mg, intravenous drip 3 to 4 hours, once every 3 days or 5 to 7 days. And then give prednisone or prednisolone oral or intravenous, tapering off. Dowling et al. Found that five of the seven patients achieved a definite clinical result within 96 hours after starting treatment. One case of binocular vision disorders, nystagmus, left leg dyskinesia and pathological reflexes of 15-year-old boy, oral prednisone 60mg treatment ineffective. 20 hours after the onset of shock therapy began to improve left eye vision, visual acuity of the left eye at 39 hours normal, right eye vision began to change