Optogenetics相关论文
目前，针对中枢神经系统疾病的常规治疗方法主要是手术治疗和药物治疗。随着光遗传学技术的出现，研究者能够在神经元以及神经环路的水......
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A Critical Time-Window for the Selective Induction of Hippocampal Memory Consolidation by a Brief Ep
Although extensively studied,the exact role of sleep in learning and memory is still not very clear.Sleep deprivation ha......
Adult male mice emit highly complex ultrasonic vocalizations (USVs) in response to female conspecifics.Such USVs,thought......
The recent development of tools to decipher the intricacies of neural networks has improved our understanding of brain f......
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Optogenetic activation of medial septal cholinergic neurons inhibits hippocampal ripple-related cell
Hippocampal CA1 sharp-wave ripples(100-250 Hz)is prominent oscillation during slow-wave sleep(SWS).It is thought to be c......
Objective Penicillin epilepsy model,whose discharge resembles that of human absence epilepsy,is one of the most useful a......
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High-frequency ripple oscillations(100-250 Hz)of local field potentials(LFPs),observed most prominently in the hippocamp......
Opotogenetic activation of adenosine A2A receptor signaling in the dorsomedial striatopallidal neuro
Striatum plays an essential role in neural control of goal-directed and habitual behavior to achieve optimal performance......
Striatopallidal pathway control of the acquisition and expression of goal-directed and habitual acti
The striatopallidal pathway is known to suppress unwanted motor programs,psychostimulant actions,but its contribution to......
Objectives: Optogenetics technology are able to conduct neuromodulation with high selectivity and high spatiotemporal re......
Neuronal population activity in the intact brain often exhibits different rhythmic patterns of distinct frequency ranges......
A disinhibitory microcircuit in the subiculum mediates secondary generalized seizures in temporal lo
Secondary generalized seizures(sGSs)are a major source of disability in temporal lobe epilepsy(TLE),but the underlying c......
Locomotion requires coordinated rhythmic motor activity throughout an animals body.By combining microfluidics and optica......
Inhibitory interneurons in the central amygdala regulate the negative affective states of morphine w
The affective states of morphine withdrawal powerfully motivate drug-seeking behavior and may trigger relapse to morphin......
Selective activation of cholinergic basal forebrain neurons induces immediate sleep-wake transitions
The basal forebrain(BF)plays a crucial role in cortical activation.However,the exact role of cholinergic BF neurons in t......
The basal ganglia(BG)are the largest structures in the forebrain and consist of four majornuclei,the striatum,globus pal......
A light-switchable transgene system could be a powerful optogenetic tool for precisely manipulating spatiotemporal gene ......
The brain consists of many interconnected areas organized into complex networks.Accurately mapping of neuronal connectiv......
OBJECTIVE Temporal lobe epilepsy(TLE)is one of the most common types of human epilepsy,and they are often resistant to c......
OBJECTIVE The nucleus accumbens(NAc),a part of basal ganglia(BG),has been reported to play a role in motivation and rewa......
A relatively small number of sleep-promoting nuclei exist in the brain.The parafacial zone was recently identified as a ......
In the nonhuman primate,area LIP is thought to be a key neural substrate for visual attention and working memory.To expl......
Innate fear plays a critical role in survival of animals.Unlike conditioned fear,the neuronal circuitry underlying innat......
Assessment of neurologic injury and the evolution of severe neurologic injury is limited in comatose or critically ill p......
Roles of Dopamine D1 Receptor-expressing Neurons in the Nucleus Accumbens in the Regulation of Wakef
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An antiepileptic circuit from entorhinal area to hippocampus for low-frequency stimulation control o
Objective To investigated the underlying network mechanisms that low frequency stimulation(LFS)of entorhinal cortex(EC)i......
相比传统电生理方法,基于光遗传学的神经调控技术具有低侵入性、可结合基因工程实现特定神经元选择性激发等优势,近年来在脑科学研......
OBJECTIVE Chronic cerebral hy⁃poperfusion can lead to progressive demyelin⁃ation and ischemic vascular dementia,yet th......
In principle,optical imaging including fluorescent and bioluminescent imaging enables such rapid,direct and sensitiv......
Driven largely by the demands of the neuroscience field,interest in optogenetic tools (i.e.,genetically encoded prot......
光遗传学是一种将光能和基因学结合的技术,采用光介导的蛋白-蛋白相互作用控制活细胞内信号转导通道的开启与关闭,或信号通路元件......
Limb loss and spinal cord injury are two debilitating conditions that continue to grow in prevalence. Pros-thetic limbs ......
In anticipation of the massive burden of neurodegenerative disease within super-aged societies, great ef-forts have been......
光遗传学是一种新型的光控细胞技术,在过去十几年已经得到广泛探索并且在神经领域得到迅速发展.许多新型工具及实验方法的出现为光......
Deep brain stimulation of the subthalamic nucleus (STN) is an effective therapy for motor deficits in Parkinson's diseas......
Spatiotemporal regulation of ubiquitin-mediated protein degradation via upconversion optogenetic nan
Protein degradation technology,which is one of the most direct and effective ways to regulate the life activities of cel......
硅基神经电极是记录神经细胞放电活动的一种实用工具.使用标准的集成电路加工技术,在宽度仅为70μm的单个硅基针上能排布上千个电......
目的利用光遗传学技术是否能有效实施光照夺获心脏,实现心脏光起搏,探讨光照强度对心脏夺获率的影响。方法取15只C57雌性小鼠,随机......
Three-photon wide-field depth-resolved excitation is used to overcome some of the limitations in conventional point-scan......
Non-invasive fluorescence retinal imaging in small animals is an important requirement for an array of translational vis......
,PET imaging on neurofunctional changes after optogenetic stimulation in a rat model of panic disord
Panic disorder (PD) is an acute paroxysmal anxiety disorder with poorly understood pathophysiology.The dorsal periaquedu......
Background:Recently,optogenetics based on genetically encoded photosensitive proteins has emerged as an innovative techn......
Chemical Physics in Living Cells — using Light to Visualize and Control Intracellular Signal Transdu
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该文从挂篮荷载计算、施工流程、支座及临时固结施工、挂篮安装及试验、合拢段施工、模板制作安装、钢筋安装、混凝土的浇筑及养生......
背景 疼痛的感知过程包括外周伤害性感受器的激活、伤害性信号在脊髓背角的转导以及痛反应相关脑区的激活.在上述3个环节中,参与伤......
