demethyl相关论文
A new lignan glycoside was isolated from the n-butanol extract of the roots and rhizomes of Sinopodophyllum emodi.On the......
Synthesis, Characterization and X-ray Crystal Structure of 2-Benzyl-7-butoxyl-9-isobutyl-1-methyl-β-
2-Benzyl-7-butoxyl-9-isobutyl-1-methyl-β-carboline bromide(H-2-65) was synthesized by the reaction of Harmine with 1-io......
The maremycin biosynthetic gene cluster has been identified in Streptomyces sp. B9173. Comparative metabolic profiling w......
Phytochemical investigations from the roots of Cynanchum stauntonii led to obtain four new C_(21) steroidal glycosides(1......
Isolation and Structure Elucidation of Autolytimycin, A New Compound Produced by Streptomyces Autoly
Autolytimycin 1 was isolated from the culture filtrate of Streptomyces autolyticus JX-47, together with two known compou......
Synthesis of 11-demethyl and 6, 6, 11-demethyl calanolides A (6-9) hav been carried out by a four-step reaction sequenc......
Using Nuclear Magnetic Resonance and MS/MS Spectroscopy for the Identification of Brodimoprim Metabo
Eight metabolites of brodimoprim (BDP) in rat urine were detected by NMR and ESI-MS/MS. They were demethyl-BDP glucuroni......
The structure of a new abietane diterpenoid, taxayunnin (1), from the barks of Taxus yunnanensis, was determined by spec......
Cytotoxicity, apoptosis induction, and mitotic arrest by a novel podophyllotoxin glucoside, 4DPG, in
Aim: To define the in vitro cytotoxic activities of 4-demethyl-picropodophyllotoxin 7’-O-β-D-glucopyranoside (4DPG), ......
自1982年Kunitomo等人从防己科植物蝙蝠葛Menispermum dauricum DC.中分离并鉴定了第一个具有7H-dibcnzo[de, h]quinolin-7-onc新......
目的:对采自中国南海的石珊瑚Tubastraeasp.的化学成分进行研究,从中寻找有生物活性的次生代谢产物。方法:用硅胶柱层析和凝胶柱层......
目的研究伞花木Eurycorymbus cavaleriei茎的化学成分。方法采用硅胶、大孔树脂、RP-C18、MCI凝胶、SephadexLH-20、半制备高效液......
为探讨美多心安代谢物总体水平在β相缓慢下降的机理,采用离体单向灌流大鼠肝脏（IPRL）研究美多心安及其代谢物在肝脏中的处置。在IPR......
本文制备了3α-溴-表苦鬼臼脂素，首次在鬼臼脂素结构修饰中在Ｃ环3-位引入取代基。其体外抑制KB细胞和L1210白血病细胞活性均高于阳性......
目的:研究罗红霉素在大鼠肝微粒体中的代谢,并考察罗红霉素及其代谢物对细胞色素P-450的影响.方法:采用超离心法制备了苯巴比妥诱......
目的研究绵枣儿Scilla scilloides全草的化学成分。方法利用硅胶柱色谱及制备液相等技术进行分离纯化,并利用波谱技术鉴定其结构。......
目的AF 5是正在研究、开发的抗焦虑药 ,本文探讨其合成方法。方法通过 3条合成路线对AF 5进行了合成。结果与结论以 (+)二氢香芹酮......
AIM: To investigate the metabolism of verapamil at low concentrations in rat liver microsomes. METHODS: Liver microsomes......
（±）－ＤｅｍｅｔｈｙｌＳａｌｖｉｃａｎｏｌ的首次全合成研究王学超，潘鑫复，崔育新，陈耀祖（兰州大学化学系，应用有机化学国家重点实验室，兰州，７３００００）关键词ＤｅｍｅｔｈｙｌＳａｌｖｉｃａｎｏｌ，全合成，选择性还原，锌促偶联反应......
Synthesis and Characterization of a Novel Podophyllotoxin Derivative Containing a Cyclohexadienone G
4β-Azido-4-demethyl-4’-O-demethyl-epipodophyllotoxin reacted with phenyliodonium diacetate in MeOH at room temperature......
Involvement of mitochondria and caspase pathways in N-demethyl-clarithromycin-induced apoptosis in h
Aim:To study the mechanisms by which N-demethyl-clarithromycin(NDC)induces human cervical cancer HeLa cell apoptosis in......
利用HPLC-MSn检测罂粟碱及其在大鼠体内(大鼠粪便)和体外(肝微粒体,肠道菌)代谢物。体内与体外的代谢物经C18小柱进行富集和纯化后......
Two new norditerpenoid alkaloids, spicatine A (1) and spicatine B (2) were isolated from the root of Aconitum spicatum.......
Three new C_(21) steroidal glycosides named inamoside E (1),inamoside F (2) and inamoside G (3) were isolated from the r......
3’-N-demethylazithromycin is an impurity in azithromycin drug. It is derived by demethylation of az- ithromycin,i. e. ,......
The deprotection of 1,3-dibenzyl-5-(N,N-dimethylamino)-6-phenyl-ethyluracil I was investigated. A practical, regioselect......
Synthesis and Biological Activity of Novel Spin Labeled Derivatives of 4′-Demethyl-4-deoxypodophyllo
Seven novel spin labeled derivatives of 4′-demethyl-4-deoxypodophyllotoxin with nitroxyl radicals(TMHPO and TMPRO) were......
消旋(±)-F18(10-chloromethyl-11-demethyl-12-oxo-calanolide A)是对天然产物(+)-calanolide A进行结构优化得到的四环香豆素类......
目的探讨地西他滨对人乳腺癌细胞中miR-5047表达及其启动子甲基化状态的影响。方法用甲基化特异性PCR(MSP)法和qRT-PCR法分别检测......
建立一种快速测定人血浆中安定与去甲安定的反相液相色谱方法，采用ＳｐｈｅｒｉｓｏｒｂＯＤＳ２柱及甲醇：水（１００：６５）作流动相，ＵＶ检测波长２２９ｎｍ，流速１．２ｍＬ／ｍｉｎ，卡马西平作内标。线性范围０．００５～１００ｍｇ／Ｌ，相对回......
Synthetic studies on 4-demethyl-qinghaosu involving preparation of key intermediateolefin 5 and its photooxygenation wer......
（±）－ＤｅｍｅｔｈｙｌＳａｌｖｉｃａｎｏｌ的首次全合成研究王学超，潘鑫复，崔育新，陈耀祖（兰州大学化学系，应用有机化学国家重点实验室，兰州，７３００００）关键词ＤｅｍｅｔｈｙｌＳａｌｖｉｃａｎｏｌ，全合成，选择性还原，锌促偶联......
